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New England Journal of Medicine’?n son say?s?nda ast?m tedavisinde uzun etkili beta-agonistlerin (long acting beta agonist, LABA) kullan?m? hakk?nda FDA’in durusunu ve guncel tedavi yaklas?m?n? ozetleyen bir perspektif yaz?s? vard?. Uzun etkili beta agonistler ast?m tedavisinde tek baslar?na kullan?ld?klar?nda (inhale kortikosteroidler eklenmeden) henuz tam anlas?lmayan bir mekanizmayla ciddi ast?m alevlenmelerini ve olum riskini art?rd?g? uzun zamand?r biliniyor. Goreceli risk dusuk olsa da (SMART cal?smas?na gore salmaterol kullanan on bin kisilik bir grupta 28 haftal?k takip suresi sonunda plasebo grubundan 8 fazla olum gerceklesmis) bu ilaclar? kullanan ast?m hastalar?n?n say?s? goz onune al?nd?g?nda sorunun klinik onemi art?yor.

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